What Makes Business Leaders Influential in 2025?
01/22/2025
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With technological advancements, shifting consumer expectations, and global interconnectedness, the role of business leaders
Scientists have identified two genetic variants associated with Raynaud’s phenomenon, which causes the fingers and toes to numb and discolored in response to cold or stress. The findings, published in the journal Nature Genetics, could lead to new treatments for the condition.
Raynaud’s phenomenon is estimated to affect up to 10% of the population, and women are more likely to develop it than men. The condition is thought to be caused by genetic and environmental factors.
In the new study, researchers analyzed the DNA of over 300,000 people, including over 15,000, with Raynaud’s phenomenon. They identified two genetic variants that were associated with the conditin.
One of the variants is located in a gene called ADRA2A, which is involved in regulating blood vessel constriction. The other variant is located in a gene called NOS1, which produces nitric oxide, a molecule that helps blood vessels relax.
The researchers found that people with one or both genetic variants were more likely to develop Raynaud’s phenomenon. The risk of developing the condition was even higher in people with both variants.
The study’s findings suggest that Raynaud’s phenomenon is a genetic disorder. The researchers believe the genetic variants they identified may contribute to the condition by causing blood vessels to constrict more easily in response to cold or stress.
The study findings could lead to new treatments for Raynaud’s phenomenon. For example, researchers could develop drugs that target the ADRA2A and NOS1 genes. Such drugs could help prevent blood vessels from constricting and improve circulation in the fingers and toes.
Scientists have identified two genetic variants that are associated with Raynaud’s phenomenon. The findings could lead to new treatments for the condition.
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